|
rs2073618
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We investigated the association between a Lys3Asn polymorphism in the OPG gene and bone mineral density (BMD), and the risk of fracture in 6695 women aged 65 yr and older participating in the Study of Osteoporotic Fractures.
|
18319311 |
2008 |
|
rs3134069
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified the T245G (rs3134069) polymorphism in the TNFRSF11B gene associated with osteoporotic fractures (vertebral fractures: p = 0.0320; non-vertebral fractures: p = 0.0005; all fractures: 0.0000).
|
25323794 |
2015 |
|
rs12475342
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified one SNP in TNFRSF11B (rs3102734), three SNPs in ESR1 (rs9397448, rs2234693, and rs1643821), two SNPs in LRP4 (rs17790156 and rs898604), and four SNPs in SPTBN1 (rs2971886, rs2941583, rs2941584, and rs12475342) were associated with all of the broadly defined osteoporotic fractures.
|
22807154 |
2012 |
|
rs2941584
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified one SNP in TNFRSF11B (rs3102734), three SNPs in ESR1 (rs9397448, rs2234693, and rs1643821), two SNPs in LRP4 (rs17790156 and rs898604), and four SNPs in SPTBN1 (rs2971886, rs2941583, rs2941584, and rs12475342) were associated with all of the broadly defined osteoporotic fractures.
|
22807154 |
2012 |
|
rs898604
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified one SNP in TNFRSF11B (rs3102734), three SNPs in ESR1 (rs9397448, rs2234693, and rs1643821), two SNPs in LRP4 (rs17790156 and rs898604), and four SNPs in SPTBN1 (rs2971886, rs2941583, rs2941584, and rs12475342) were associated with all of the broadly defined osteoporotic fractures.
|
22807154 |
2012 |
|
rs17790156
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified one SNP in TNFRSF11B (rs3102734), three SNPs in ESR1 (rs9397448, rs2234693, and rs1643821), two SNPs in LRP4 (rs17790156 and rs898604), and four SNPs in SPTBN1 (rs2971886, rs2941583, rs2941584, and rs12475342) were associated with all of the broadly defined osteoporotic fractures.
|
22807154 |
2012 |
|
rs1643821
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified one SNP in TNFRSF11B (rs3102734), three SNPs in ESR1 (rs9397448, rs2234693, and rs1643821), two SNPs in LRP4 (rs17790156 and rs898604), and four SNPs in SPTBN1 (rs2971886, rs2941583, rs2941584, and rs12475342) were associated with all of the broadly defined osteoporotic fractures.
|
22807154 |
2012 |
|
rs2234693
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified one SNP in TNFRSF11B (rs3102734), three SNPs in ESR1 (rs9397448, rs2234693, and rs1643821), two SNPs in LRP4 (rs17790156 and rs898604), and four SNPs in SPTBN1 (rs2971886, rs2941583, rs2941584, and rs12475342) were associated with all of the broadly defined osteoporotic fractures.
|
22807154 |
2012 |
|
rs13182402
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that a SNP, rs13182402 within the ALDH7A1 gene on chromosome 5q31, was strongly associated with OF with evidence combined GWAS and replication studies (P = 2.08x10(-9), odds ratio = 2.25).
|
20072603 |
2010 |
|
rs1213308971
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We examined the associations between the Glu298Asp polymorphism of NOS3, indices of bone strength, and the incidence of fracture among 6691 women aged 65 years and older enrolled in the Study of Osteoporotic Fractures.
|
16503213 |
2006 |
|
rs1427938321
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We examined the associations between the Glu298Asp polymorphism of NOS3, indices of bone strength, and the incidence of fracture among 6691 women aged 65 years and older enrolled in the Study of Osteoporotic Fractures.
|
16503213 |
2006 |
|
rs1799983
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We examined the associations between the Glu298Asp polymorphism of NOS3, indices of bone strength, and the incidence of fracture among 6691 women aged 65 years and older enrolled in the Study of Osteoporotic Fractures.
|
16503213 |
2006 |
|
rs281865264
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We examined the associations between the Glu298Asp polymorphism of NOS3, indices of bone strength, and the incidence of fracture among 6691 women aged 65 years and older enrolled in the Study of Osteoporotic Fractures.
|
16503213 |
2006 |
|
rs876657777
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We examined the associations between the Glu298Asp polymorphism of NOS3, indices of bone strength, and the incidence of fracture among 6691 women aged 65 years and older enrolled in the Study of Osteoporotic Fractures.
|
16503213 |
2006 |
|
rs1800629
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We evaluated the association between a G-308A polymorphism (rs1800629) at the TNFA locus and osteoporosis phenotypes in 4306 older women participating in the Study of Osteoporotic Fractures.
|
15797957 |
2005 |
|
rs4986791
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To examine the frequency of TLR4 C1196T genotypes in postmenopausal osteoporotic and non-osteoporotic Polish women and to investigate the possible relationship between C1196T polymorphism, bone mineral density (BMD) and the incidence of osteoporotic fractures in this group of patients.
|
25931355 |
2015 |
|
rs587777005
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Through whole-genome sequencing of Icelandic individuals, we found a rare nonsense mutation within the leucine-rich-repeat-containing G-protein-coupled receptor 4 (LGR4) gene (c.376C>T) that is strongly associated with low BMD, and with osteoporotic fractures.
|
23644456 |
2013 |
|
rs1800544
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The present study aimed to investigate the association of rs1800544 polymorphism of α2A-AR gene with BMD and BTMs in the Chinese elderly population with osteoporosis (OP) or with osteoporotic fractures.
|
30033441 |
2018 |
|
rs3102734
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The most significant polymorphism was rs3102734, with increased risk of osteoporotic fractures (odds ratio, 1.35; 95% confidence interval [CI], 1.17-1.55, Bonferroni p = 2.6 × 10(-4) ).
|
22807154 |
2012 |
|
rs2908004
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The main finding was that of significant differences in the polymorphisms of the WNT16 rs2908004 genetic variant, notably, the less frequent presence of TC allele in women with a greater risk of osteoporotic fractures.
|
31309515 |
2019 |
|
rs3917
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The findings showed rs3917 polymorphism interfered with the interaction between COL1A2 mRNA and miR-382, and minor allele is associated with a reduced risk of osteoporotic fracture.
|
30825231 |
2019 |
|
rs11898505
|
|
|
0.020 |
GeneticVariation |
BEFREE |
SPTBN1 (rs11898505) and SOST (rs1107748) were associated with osteoporotic fracture.
|
20554715 |
2010 |
|
rs1800012
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Over the past two decades, a low frequency variant (rs1800012) within the first intron of the type I collagen alpha 1 (COLIA1) gene has been implicated in lower areal BMD (aBMD) and increased risk of osteoporotic fracture.
|
30711642 |
2019 |
|
rs366512
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our study provides supportive evidence for the contribution of <i>PDLIM4</i> gene polymorphisms to the susceptibility to osteoporotic fracture and suggests that rs270611 and rs3900945 are genetic risk factors, while rs366512 might be a genetic protective factor against osteoporotic fracture in elderly Han individuals.
|
30578378 |
2019 |
|
rs3900945
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our study provides supportive evidence for the contribution of <i>PDLIM4</i> gene polymorphisms to the susceptibility to osteoporotic fracture and suggests that rs270611 and rs3900945 are genetic risk factors, while rs366512 might be a genetic protective factor against osteoporotic fracture in elderly Han individuals.
|
30578378 |
2019 |